Tumor Necrosis Factor-α Converting Enzyme/ADAM 17 Mediates MUC1 Shedding
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منابع مشابه
Tumor Necrosis Factor- –Converting Enzyme (ADAM17) Mediates GPIb Shedding From Platelets In Vitro and In Vivo
Interaction of the platelet receptor glycoprotein (GP) Ib-V-IX with von Willebrand factor exposed at a site of vascular injury is an essential step in the initiation of a hemostatic plug. Proteolytic cleavage (shedding) of the GPIb subunit was first described 25 years ago, the protease mediating this event as well as its physiological function, however, have not been elucidated. We reported rec...
متن کاملMacrophage-derived Tumor Necrosis Factor-α mediates diabetic renal injury
Monocyte/macrophage recruitment correlates strongly with the progression of diabetic nephropathy. Tumor necrosis factor-α (TNF-α) is produced by monocytes/macrophages but the direct role of TNF-α and/or macrophage-derived TNF-α in the progression of diabetic nephropathy remains unclear. Here we tested whether inhibition of TNF-α confers kidney protection in diabetic nephropathy via a macrophage...
متن کاملMonocyte Tumor Necrosis Factor-α–Converting Enzyme Catalytic Activity and Substrate Shedding in Sepsis and Noninfectious Systemic Inflammation*
OBJECTIVES To determine the effect of severe sepsis on monocyte tumor necrosis factor-α-converting enzyme baseline and inducible activity profiles. DESIGN Observational clinical study. SETTING Mixed surgical/medical teaching hospital ICU. PATIENTS Sixteen patients with severe sepsis, 15 healthy volunteers, and eight critically ill patients with noninfectious systemic inflammatory response...
متن کاملSelective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor -converting enzyme
Iwata M, Silva Enciso J, Greenberg BH. Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor -converting enzyme. Am J Physiol Cell Physiol 297: C1318–C1329, 2009. First published September 16, 2009; doi:10.1152/ajpcell.00036.2009.—Angiotensin-converting enzyme 2 (ACE2) is a newly identified regulator of the renin-angiotensin system....
متن کاملSelective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme.
Angiotensin-converting enzyme 2 (ACE2) is a newly identified regulator of the renin-angiotensin system. This type I membrane-anchored protein has a catalytically active ectodomain that undergoes shedding. Tumor necrosis factor alpha-converting enzyme (TACE) has been shown to be involved in ACE2 shedding. Although pathophysiological significance of ACE2 shedding has been suggested, regulation of...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m208326200